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KMID : 1009020150130020129
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Clinical Psychopharmacology and Neuroscience
2015 Volume.13 No. 2 p.129 ~ p.137
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Omega-3 Polyunsaturated Fatty Acids in Prevention of Mood and Anxiety Disorders
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Kuan-Pin Su
Yutaka Matsuoka
Pae Chi-Un
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Abstract
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Psychiatric disorders in general, and major depression and anxiety disorders in particular, account for a large burden of disability, morbidity and premature mortality worldwide. Omega-3 polyunsaturated fatty acids (PUFAs) have a range of neurobiological activities in modulation of neurotransmitters, anti-inflammation, anti-oxidation and neuroplasticity, which could contribute to psychotropic effects. Here we reviewed recent research on the benefits of omega-3 PUFA supplements in prevention against major depression, bipolar disorders, interferon-α-induced depression patients with chronic hepatitis C viral infection, and posttraumatic stress disorder. The biological mechanisms underlying omega-3 PUFAs’ psychotropic effects are proposed and reviewed. Nutrition is a modifiable environmental factor that might be important in prevention medicine, which have been applied for many years in the secondary prevention of heart disease with omega-3 PUFAs. This review extends the notion that nutrition in psychiatry is a modifiable environmental factor and calls for more researches on prospective clinical studies to justify the preventive application of omega-3 PUFAs in daily practice.
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KEYWORD
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Omega-3 (N-3) polyunsaturated fatty acids (PUFA), Depression, Anxiety disorders, Psychotic disorders, Clinical trials
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